DNA Methylation of Interleukin-6 (IL-6) promoter in the Leukocytes is reduced in prehypertensive young adults

Wan Omar, Wan Fatein Nabeila and Mohd Shah, Azarisman Shah and Ab Rahman, Jamalludin and A.Talib, Norlelawati and Mohd. Shah, Aida Nur Sharini and Abdullah, Aszrin (2019) DNA Methylation of Interleukin-6 (IL-6) promoter in the Leukocytes is reduced in prehypertensive young adults. In: Hypertension Jeju 2019, 17th-18th May 2019, Jeju, Korea. (Unpublished)

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Abstract

Background: Prehypertension is associated with increased risk of cardiovascular disease. Chronic inflammation plays a role in the pathophysiology of essential hypertension, with epigenetic dysregulation involvement. However, its role in prehypertensive state is not known. The aim of this study was to investigate the association between DNA methylation level of IL-6 promoter in prehypertensive (PreHT) and normotensive (NT) young adults. Method: We recruited 80 NT and 80 PreHT healthy subjects age 18-45 years in Kuantan, Pahang in an observational cross-sectional study. We analysed the DNA methylation level of IL-6 of peripheral leukocytes using bisulphite conversion and MethyLight assay. The difference in IL-6 promoter methylation level between the two groups was analysed. Result: The mean age of NT was 30.8 (6.60) years and PreHT was 31.3 (6.9) years. There was no statistical difference in age between the two groups (p=0.655). The mean blood pressure was 110(8)/73(5) mmHg in NT and 125(7)/82(5) mmHg in PreHT. The IL-6 promoter interleukin-6methylation level was significantly lower in preHT compared to NT subjects (p<0.001). Conclusion: Our study indicates that hypomethylation of IL-6 promoter was associated with preHT in young adults. IL-6 methylation could prove to be an important indicator for future hypertension in these subjects. Gene expression study and longitudinal study are warranted to establish the methylation effect on IL-6 expression over time.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	7963/82000
Uncontrolled Keywords:	Prehypertension, epigenetics, MethyLight, inflammation
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Internal Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Medicine
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	13 Aug 2020 15:54
Last Modified:	13 Aug 2020 15:54
URI:	http://irep.iium.edu.my/id/eprint/82000

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