Sepsis mortality score using multi-marker approach for the prediction of mortality in septic critically ill patients

Wan Muhd Shukeri, Wan Fadzlina and Mat Nor, Mohd Basri and Md Ralib, Azrina (2017) Sepsis mortality score using multi-marker approach for the prediction of mortality in septic critically ill patients. IIUM Medical Journal Malaysia, 16 (Supplement 1). p. 36. ISSN 1823-4631

PDF (Meeting Abstract) - Published Version Restricted to Repository staff only Download (64kB) | Request a copy

Abstract

Introduction: Clinical scoring methods such as the Sequential Organ Failure Assessment (SOFA) score are frequently used to predict outcome in sepsis, with limited capacity. Further tools for risk assessment of septic critically ill patients would thus be useful. Our purpose was to derive a scoring method i.e. Sepsis Mortality Score using multimarker approach for the prediction of 30-day mortality in septic critically ill patients, and compare its performance to the SOFA score. Materials and method: This prospective study included 159 septic patients admitted to an intensive care unit (ICU). Leukocytes count, procalcitonin (PCT), interleukin-6 (IL-6), paraoxonase (PON) and arylesterase (ARE) were assayed from blood draws obtained on ICU presentation. Logistic regression was used to identify an optimal combination of these biomarkers to create the Sepsis Mortality Score, which was the predicted probability of 30-day mortality. Results: The 30-day mortality rate was 28.9%. In the logistic regression model, leukocytes count, PCT, IL-6 and ARE remained as independent biomarkers. The areas under curve (AUC) of the Sepsis Mortality Score derived from these biomarkers was 0.814 (95% confidence interval (CI) 0.736-0.892), better than the SOFA score (AUC 0.767 (95% CI 0.677-0.857). Addition of Sepsis Mortality Score on SOFA score showed an even better prediction of 30-day mortality (AUC 0.845 (95% CI 0.772-0.919)). Conclusion: Multi-marker approach using leukocytes count, PCT, IL-6 and ARE, combined with the SOFA score, might provide a valuable tool for risk assessment of septic critically ill patients.

Item Type:	Article (Meeting Abstract)
Additional Information:	5608/81806
Subjects:	R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User:	Dr. Mohd Basri Mat Nor
Date Deposited:	24 Jul 2020 11:01
Last Modified:	24 Jul 2020 11:01
URI:	http://irep.iium.edu.my/id/eprint/81806

Actions (login required)

View Item