Derivation of a new bioscore for predicting mortality in sepsis

Wan Muhd Shukeri, Wan Fadzlina and Md Ralib, Azrina and Mat Nor, Mohd Basri (2018) Derivation of a new bioscore for predicting mortality in sepsis. IIUM Medical Journal Malaysia, 17 (Supplementary Issue no. 1). p. 40. ISSN 1823-4631

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Abstract

Introduction: Currently, there is a lack of clinically feasible and reliable method for discriminating outcome in sepsis. We aimed to derive a new bioscore for predicting 30-day mortality in sepsis using a combination of biomarkers and clinical indexes. Materials and Methods: This secondary analysis of a prospectively collected data included 159 septic patients admitted to an intensive care unit (ICU). We collected data for key variables considered for inclusion in the score which included: age, sex, source of admission, comorbidities, microorganism, bacteraemia, site of infection, septic shock status, baseline Simplified Acute Physiological Score II, Sequential Organ Failure Assessment (SOFA) score (total and organ sub-scores), C-reactive protein, procalcitonin and interleukin-6 (IL-6). Approximate quintiles of each variable were assigned points based on the strength of their association with 30-day mortality. Results: Based on the statistical significance in the logistic regression model, the final score used candidate variables of age, central nervous system and liver SOFA sub-scores and IL-6. The bioscore predicted 30-day mortality with a very good performance [area under the receiver operating characteristic curve 0.814 (95% CI 0.745-0.871, p <0.0001)] in our sepsis cohort. A bioscore greater than 4 predicted 30-day mortality with 80.4% sensitivity, 69.9% specificity, 2.67 positive likelihood ratio and 0.28 negative likelihood ratio. As the score increased, so did mortality rate. Conclusion: A new bioscore combining age, central nervous system and liver SOFA sub-scores and IL-6 measured on ICU admission improves prediction of mortality in sepsis.

Item Type:	Article (Meeting Abstract)
Additional Information:	5608/81801
Subjects:	R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User:	Dr. Mohd Basri Mat Nor
Date Deposited:	17 Aug 2020 11:25
Last Modified:	17 Aug 2020 11:25
URI:	http://irep.iium.edu.my/id/eprint/81801

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