Apolipoprotein E gene polymorphism influenced glycemic status among Malaysians

Rahman, K. M. Hafizur and Hossain, Md Sanower and Haque, Nazmul and Abdul Razak, Tariq and Ahmad, Hussain (2019) Apolipoprotein E gene polymorphism influenced glycemic status among Malaysians. Biomedical Research and Therapy, 6 (7). pp. 3307-3314. ISSN 2198-4093

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Abstract

Aim: In the last decade Apolipoprotein E (APOE) gene polymorphism has been identified as one ofthe risk factors of type 2 diabetes mellitus (T2DM). Though more than 11% population of Malaysiaare suffering from T2DM, there is inadequate data on the correlation between theAPOEgene poly-morphism and pathogenesis of diabetes among Malaysians. Hence, in this study we aimed tofind out the association between the frequencies ofAPOEallele and fasting blood glucose (FBG)concentration among subjects with T2DM.Methods: A total of 102 subjects were recruited intotwo distinct groups, 51 in diabetes (cases) and 51 in non-diabetes (control) group. Their fastingblood sample was tested for FBG, whileAPOEgenotyping was carried out using restriction fragmentlength polymorphism technique. Predictive Analytics Software (PASW) statistics, version 18.0, wasused for statistical analyses.Results: There was no association betweenAPOEalleles and T2DM;odd ratios for the e2, e3 and e4 alleles were 1.51 (95%CI: 0.615-3.706), 0.77 (95%CI: 0.431-1.375) and1.12 (95%CI: 0.584-2.131) respectively. The highest mean FBG was found in subjects with e2 alleles,followed by e4 and e3 alleles in both cases and control groups. Both e2 and e4 alleles were sig-nificantly linked to higher mean FBG (p=0.03 and 0.04 for the respectively) compared to e3 allelein diabetes group.Conclusions: Although theAPOEgene was not found to be associated withT2DM, it may influence glycemic status among subjects.

Item Type:	Article (Journal)
Additional Information:	3798/79882
Uncontrolled Keywords:	APOE, FBG, polymorphism, T2DM
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine
Depositing User:	Faizah Shahbudin
Date Deposited:	27 Mar 2020 11:48
Last Modified:	27 Mar 2020 11:48
URI:	http://irep.iium.edu.my/id/eprint/79882

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