Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases

Mansor, Nur Izzati and Nordin, Norshariza and Mohamed, Farahidah and Ling, King-Hwa and Rosli, Rozita and Hassan, Zurina (2019) Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases. Current Drug Delivery, 16 (8). pp. 698-711. ISSN 1567-2018 (In Press)

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Abstract

Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases.

Item Type:	Article (Journal)
Additional Information:	4341/79799
Uncontrolled Keywords:	Blood-brain barrier; Central nervous system; Colloidal carrier system; Drug delivery system; Nanoparticles; Neurodegenerative diseases
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Engku Norulizati Engku Aziz
Date Deposited:	24 Jun 2020 15:53
Last Modified:	25 Jun 2020 08:47
URI:	http://irep.iium.edu.my/id/eprint/79799

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