Determination of fracture risk on patient-specific model of femur with osteogenesis imperfecta

Ahmad, Siti Fatima Zahra’ and Mat Som, Mohd Hanafi and Basaruddin, Khairul Salleh and Daud, Ruslizam and Awang, Mohd Shukrimi (2019) Determination of fracture risk on patient-specific model of femur with osteogenesis imperfecta. In: International Conference on Biomedical Engineering, 26 - 27 Aug 2019, Penang Island.

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Abstract

Osteogenesis Imperfecta (OI) is a group of genetic disorder that affects the bones. It causes bone to break easily. For severe case, it can lead the patient to death. However, doctors still have no quantitative method to predict fractures. Therefore, this study aims to investigate the fracture risk for OI femoral bone under load of activities in daily living and various loading direction. A finite element model reconstructed from radiography CT images was developed. The variations of daily activities were subjected to the femoral model. In standing and walking configuration, the model of OI has the ability to perform without having any fracture. However, during jumping, both configurations cause the OI femoral fractured. We can conclude that when the OI patients more active in their daily life, the higher chances for fracture to occur. The risk of fracture increases with increasing the intensity of the activity. Thus, early prediction of fracture risk could help prevent or treating fracture for OI patients.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	3447/79607
Uncontrolled Keywords:	Daily activity, early prediction, fracture risks, genetic disorders, loading direction, osteogenesis imperfecta, patient specific model, quantitative method
Subjects:	R Medicine > RD Surgery > RD701 Orthopedics T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine
Depositing User:	Assoc Prof Mohd Shukrimi Awang
Date Deposited:	18 Mar 2020 09:05
Last Modified:	14 Jul 2020 16:38
URI:	http://irep.iium.edu.my/id/eprint/79607

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