Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king

Mhd Bakri, Yuhanis and Abdulaimi, Ahmed Kareem Obaid and Syed Abdul Azziz, Saripah Salbiah and Nafiah, Mohd Azlan and Abdulla Aowda, Saadon and Hazim, Muhammad and Awang, Khalijah and Hashim, Yumi Zuhanis Has-Yun and Abbas, Phirdaous (2019) Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king. Research Journal of Pharmacy and Technology, 12 (9). pp. 4129-4134. ISSN 0974-3618 E-ISSN 0974-360X

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Abstract

This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectroscopic techniques including NMR, MS, IR, UV and comparison with literature. A study on the barks of A. cylindrica has found eleven known compounds were identified as stigmasterol (1), isoursuline (2), cyathocaline (3), kinabaline (4), muniranine (5), isooncodine (6), iraqiine (7), O-methylmoschatoline (8), kareemine (9), atherospermidine (10) and N-methylouregidione (11). The cytotoxic effect of hexane, DCM and methanol of bark of A. cylindrica as well as the isolated compounds; 1, 2, 3, 4, 5, 7, 8, 9 and 10 were estimated on MCF-7 human breast cancer cells and isoursuline possessed the most potent inhibitory activity with IC50 value of 33 µg/ml. Eight compounds 1, 3, 4, 5, 6, 8, 10 and 11 displayed moderate inhibitory activity effect with IC50 < 100 μM against xanthine oxidase. As a conclusion, eleven compounds have been isolated from the bark of A. cylindrica King. Some of the compounds also showed potential against cytotoxicity and xanthine oxidase inhibitory activities. The findings of this study can enhance the understanding of the chemotaxonomy aspect of the A. cylindrica as well as its potential in traditional and modern medicine

Item Type:	Article (Journal)
Additional Information:	3774/79578
Uncontrolled Keywords:	Alphonsea cylindrica, Alkaloid, Cytotoxic, MCF-7, Xanthine Oxidase
Subjects:	R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	DR YUMI ZUHANIS HAS-YUN HASHIM
Date Deposited:	16 Mar 2020 17:14
Last Modified:	16 Mar 2020 17:14
URI:	http://irep.iium.edu.my/id/eprint/79578

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