Barthasarathy, Piravin Raj and Ahmad Shahizam, Zayd and Ihda Uswatun Shalihah, Shohibuddin and Wan Salim, Wan Wardatul Amani (2019) Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing. In: IIUM Kuantan Research Day 2019, 19-23 Oct 2019, Grand Hall , Level 1, Office of the Campus, IIUM Bandar Indera Mahkota, 25200 Kuantan. (In Press)
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Abstract
Nanotechnology has been broadly acknowledged in scaffold development for wound healing applications. Nanofibers-based scaffolds are highly valued for its mechanical and biological properties. Nonetheless, nanofibers composed of different nanofillers posed enormous challenge in emulating the architecture of extracellular matrix. In our study, we have capitalized the unique property of graphene oxide (GO) and poly(3,4- ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) as nanofillers. Polyvinyl alcohol (PVA), PVA-GO and PVA-GO-PEDOT:PSS composites were electrospun into nanofibers of varying morphological, structural, and mechanical properties. The resulting nanofiber films were analysed using FESEM imaging, FTIR spectroscopy, and Raman spectroscopy. The morphology of resultant nanofibers revealed no evidence of beading and the nanofiber diameters were normally distributed with reasonably low variance (n = 50). The average diameter of PVA nanofibers was 248 ± 51 nm, which increased to 270 ± 94 nm when GO was added, and to 275 ± 140 nm when PEDOT:PSS was incorporated into the electrospun solution. Upon soaking in PBS, PVA nanofibers showed pores formation, while no pores were visible in PVA-GO and PVA-GO-PEDOT:PSS nanofibers. As for FTIR spectra, we observed the broadening of -OH bond and shift to higher wavelength in both solution and nanofibers. Additionally, Raman spectroscopy analysis showed splitting and shifting of D band (1362 and 1409 cm-1) and G band (1504 and 1586 cm-1) in PVA-GO-PEDOT:PSS nanofibers. As for PVAGO nanofibers, we observed shifting of D band (1311 cm-1) and G band (1593 cm-1), with no evidence of band splitting. Our study indicate that PVA-GO-PEDOT:PSS nanofiber has similar tensile strength measurement to native skin, while exhibiting a combination of unique property of PVA, GO and PEDOT:PSS. Hence, we deduce that PVA-GO-PEDOT:PSS nanofiber can serve as a initial template for further modifications and subsequently used to promote wound closure.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Uncontrolled Keywords: | Electrospinning, PVA-graphene oxide, PEDOT:PSS, nanofibers, wound healing |
| Subjects: | R Medicine > RD Surgery > RD92 Wounds and injuries T Technology > TP Chemical technology > TP248.13 Biotechnology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Engineering > Department of Biotechnology Engineering |
| Depositing User: | Dr Wan Wardatul Amani Wan Salim |
| Date Deposited: | 04 Feb 2020 13:21 |
| Last Modified: | 04 Feb 2020 13:23 |
| URI: | http://irep.iium.edu.my/id/eprint/77686 |
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