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Disseminated histoplasmosis mimicking an acute appendicitis

Marzukie, Marsilla Mariaty and Ahmad Affandi, Khairunisa and Yahaya, Azyani and Periyasamy, Petrick (2019) Disseminated histoplasmosis mimicking an acute appendicitis. Malaysian Journal of Pathology, 41 (2). pp. 223-227. ISSN 0126-8635

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Introduction: Histoplasmosis can present in a myriad of clinical manifestations, which often makes its diagnosis difficult and occasionally, deceptive. Case Report: We describe a case of a 33 years old gentleman who was clinically diagnosed as acute appendicitis at initial presentation in view of a one-week history of fever, right lower quadrant abdominal pain- and guarding at right iliac fossa. He had thrombocytopenia and lymphopenia on presentation. Mesenteric lymphadenitis and small bowel lesion were found intraoperatively, which was respectively biopsied and resected. Histopathological result confirms disseminated histoplasmosis. Retroviral screen was positive. He was treated with amphotericin B for one week, subsequently switched to oral itraconazole, followed by initiation of highly active antiretroviral therapy (HAART). Discussion: This case illustrates the various nature of histoplasmosis presentation. A high index of suspicion is needed to clinch the diagnosis and subsequently institute prompt treatment as disseminated disease can be fatal if left untreated in an immunosuppressed host.

Item Type: Article (Case Report)
Additional Information: 7120/77510
Uncontrolled Keywords: Disseminated Histoplasmosis; Gastrointestinal Histoplasmosis; Histoplasma capsulatum
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Dr Khairunisa Ahmad Affandi
Date Deposited: 31 Dec 2019 11:24
Last Modified: 31 Dec 2019 11:24
URI: http://irep.iium.edu.my/id/eprint/77510

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