Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney

Wan Salleh, Wan Muhamad Salahudin and A.Talib, Norlelawati and Abdullah, Nor Zamzila and Aung, Sanda and Buyong, Zunariah (2019) Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney. In: 28th Scientific Conference of Microscopy Society Malaysia, 18th - 20th December 2019, Swiss Garden Beach Resort, Kuantan Pahang. (Unpublished)

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Abstract

Introduction: Monosodium methylarsonate (MSMA) is an organic arsenic widely used in agriculture. Humans are exposed to arsenic through drinking water and anthropogenic activities. Chronic exposure to inorganic arsenic has been linked with multiple health problems. However, studies focusing on organic arsenic effects on kidneys were limited. Objective: To determine the effects of organic arsenic exposure on rat’s kidney. Materials and Method: Twelve male Sprague-Dawley rats were divided into control (n=6) and treated (n=6) groups. Control group was given daily oral gavage of distilled water and treated group was given daily oral gavage of MSMA at 63.0 mg/kg body weight, which was equivalent of 1/30 LD50 of MSMA. After four months, rats urines were collected using metabolic cage and both groups were sacrificed. The urines were analyzed using enzyme-linked immunosorbent assay (ELISA) for neutrophil gelatinase-associated lipocalin (NGAL) biomarkers for kidney injury. The kidneys were harvested for light microscopy study. Results: Urine NGAL significantly higher (p-value <0.05) in treated groups. Light microscopy showed focal glomerular and tubular changes in treated groups. Conclusion: Chronic low dose organic arsenic exposure induced kidney injury.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	6299/77438
Uncontrolled Keywords:	organic arsenic, chronic kidney injury, monosodium mehtylarsonate.
Subjects:	R Medicine > RA Public aspects of medicine > RA1190 Toxicology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	dr wan muhamad salahudin wan salleh
Date Deposited:	23 Dec 2019 16:56
Last Modified:	04 Feb 2020 08:22
URI:	http://irep.iium.edu.my/id/eprint/77438

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