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Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors

Syed Abdul Azziz, Saripah Salbiah and Mukhtar, Mat Ropi and A.Hadi, A.Hamid and Mhd Bakri, Yuhanis and Abdulaimi, Ahmed Kareem Obaid and Awang, Khalijah and Hashim, Yumi Zuhanis Has-Yun (2019) Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors. Research Journal of Pharmacy and Technology, 12 (1). pp. 113-116. ISSN 0974-3618

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A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GCMS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes.

Item Type: Article (Journal)
Additional Information: 3774/77248
Uncontrolled Keywords: Popowia perakensis King; Annonaceae, azaanthraquinones; Simple isoquinolone, DPP IV activity.
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): International Institute for Halal Research and Training (INHART)
Date Deposited: 09 Jan 2020 14:41
Last Modified: 23 Jan 2020 15:15
URI: http://irep.iium.edu.my/id/eprint/77248

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