Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines

Meenakshi Sundram, Tamil Chelvan and Zakaria, Mohd Hazim and Mohd Nasir, Mohd Hamzah (2019) Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines. Science Heritage Journal (GWS), 3 (2). pp. 10-14. ISSN 2521-0858 E-ISSN 2521-0866

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Abstract

Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic activity of C. mangga and B. rotunda ethanolic extracts. Initially, in this study, ethanolic extracts from rhizomes of C. mangga and B. rotunda were obtained through Soxhlet extraction method. 12.6% and 3.5% of crude extract were obtained from C. mangga and B. rotunda respectively. For MTT assay, the IC50 values are 207µg/ml and 31.96 µg/ml for C. mangga and B. rotunda respectively. Meanwhile for the antioxidant activity using DPPH assay, C. mangga showed higher antioxidant activity with IC50 values of 1073µg/ml compared to B. rotunda with IC50 values of 578µg/ml. It can be concluded both extracts showed low inhibitory effect on MCF-7 cancer cells growth and DPPH free radical activity.

Item Type:	Article (Journal)
Additional Information:	5522/76737
Uncontrolled Keywords:	Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic activity of C. mangga and B. rotunda ethanolic extracts. Initially, in this study, ethanolic extracts from rhizomes of C. mangga and B. rotunda were obtained through Soxhlet extraction method. 12.6% and 3.5% of crude extract were obtained from C. mangga and B. rotunda respectively. For MTT assay, the IC50 values are 207µg/ml and 31.96µg/ml for C. mangga and B. rotunda respectively. Meanwhile for the antioxidant activity using DPPH assay, C. mangga showed higher antioxidant activity with IC50 values of 1073µg/ml compared to B. rotunda with IC50 values of 578µg/ml. It can be concluded both extracts showed low inhibitory effect on MCF-7 cancer cells growth and DPPH free radical activity.
Subjects:	Q Science > QH Natural history > QH301 Biology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr Mohd Hamzah Mohd Nasir
Date Deposited:	27 Dec 2019 10:32
Last Modified:	24 Mar 2020 13:35
URI:	http://irep.iium.edu.my/id/eprint/76737

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