Infections by multidrug-resistant Gram-negative bacteria: what's new in our arsenal and what's in the pipeline?

Koulenti, Despoina and Song, Andrew and Ellingboe, Aaron and Abdul-Aziz, Mohd Hafiz and Harris, Patrick and Gavey, Emile S. and Lipman, Jeffrey (2019) Infections by multidrug-resistant Gram-negative bacteria: what's new in our arsenal and what's in the pipeline? International Journal of Antimicrobial Agents, 53 (3). pp. 211-224. ISSN 0924-8579 E-ISSN 1872-7913

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Abstract

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire and spread new resistance mechanisms. Treating infections caused by Gram-negative bacteria is a challenge for medical practitioners and increases patient mortality and cost of care globally. This vulnerability, along with strategies to tackle antimicrobial resistance development, prompts the development of new antibiotic agents and exploration of alternative treatment options. This article summarises the new antibiotics that have recently been approved for Gram-negative bacterial infections, looks down the pipeline at promising agents currently in phase I, II, or III clinical trials, and introduces new alternative avenues that show potential in combating multidrug-resistant Gram-negative bacteria.

Item Type:	Article (Journal)
Additional Information:	6561/76366
Uncontrolled Keywords:	Ceftolozane/tazobactam; Ceftazidime/avibactam Meropenem/vaborbactam; Plazomicin; Eravacycline; Multidrug-resistant; Gram-negative bacteria
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Mohd Hafiz Abdul Aziz
Date Deposited:	19 Nov 2019 18:49
Last Modified:	19 Nov 2019 18:49
URI:	http://irep.iium.edu.my/id/eprint/76366

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