Cerebral small vessel disease (CSVD) – lessons from the animal models

Mustapha, Muzaimi and Che Mohd Nassir, Che Mohd Nasril and Aminuddin, Niferiti and Ahmad Safri, Amanina and Mohamad Ghazali, Mazira (2019) Cerebral small vessel disease (CSVD) – lessons from the animal models. Frontiers in Physiology, 10. pp. 1-29. ISSN 1664042X

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Abstract

Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings resulting from pathological processes of various etiologies affecting cerebral arterioles, perforating arteries, capillaries, and venules. Unlike large vessels, it is a challenge to visualize small vessels in vivo, hence the difficulty to directly monitor the natural progression of the disease. CSVD might progress for many years during the early stage of the disease as it remains asymptomatic. Prevalent among elderly individuals, CSVD has been alarmingly reported as an important precursor of full-blown stroke and vascular dementia. Growing evidence has also shown a significant association between CSVD’s radiological manifestation with dementia and Alzheimer’s disease (AD) pathology. Although it remains contentious as to whether CSVD is a cause or sequelae of AD, it is not far-fetched to posit that effective therapeutic measures of CSVD would mitigate the overall burden of dementia. Nevertheless, the unifying theory on the pathomechanism of the disease remains elusive, hence the lack of effective therapeutic approaches. Thus, this chapter consolidates the contemporary insights from numerous experimental animal models of CSVD, to date: from the available experimental animal models of CSVD and its translational research value; the pathomechanical aspects of the disease; relevant aspects on systems biology; opportunities for early disease biomarkers; and finally, converging approaches for future therapeutic directions of CSVD.

Item Type:	Article (Review)
Additional Information:	6716/76306
Uncontrolled Keywords:	animal models; biomarkers; cerebral small vessel disease (CSVD); systems biology; therapeutic
Subjects:	Q Science > QP Physiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Pharmacy
Depositing User:	Dr Niferiti Aminuddin
Date Deposited:	25 Nov 2019 12:23
Last Modified:	28 Feb 2020 16:28
URI:	http://irep.iium.edu.my/id/eprint/76306

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