Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia

Ahmad, Mastura and Zin, Che Suraya and Ab Rahman, Ab Fatah (2019) Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur. (Unpublished)

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Abstract

Introduction: Patients using CAPD are commonly associated with peritonitis. Peritonitis is a significant cause of morbidity, mortality and permanent transfer to haemodialysis in these patients. However, little is known about the utilization of antibiotic for the treatment of peritonitis in patients using CAPD. Objectives: This study aimed to evaluate the patterns of intra-peritoneal antibiotics utilization for the treatment of peritonitis in CAPD patients. Materials and Methods: This was a retrospective study conducted at a tertiary hospital setting in Malaysia. Medical records of CAPD patients who were diagnosed with peritonitis and registered with National Kidney Registry during 2013 to 2018 were reviewed. Types of antibiotics used and its dose and duration were recorded and reported using the ATC/DDD system. Results: A total of 105 peritonitis episodes were recorded from 72 patients. The most common first line empiric combinations used were ceftazidime/cefazolin (42%, n=), followed by cefepime/cefazolin (32%,n=) and ceftazidime/cloxacillin (27%, n=). For the definite therapy after obtaining the culture and sensitivity report demonstrated that vancomycin was the most prescribed (33.64%, n=), followed by meropenem (14.95%, n=) and ciprofloxacin (% , n=) . Although ciprofloxacin was the least antibiotic prescribed for CAPD-related peritonitis, the DDD/100patient-days estimates showed that its therapeutic intensity were the highest. Conclusion: There were various intraperitoneal antibiotics used for CAPD-related peritonitis and the most common empirical therapy was the combination of ceftazidine and ceftazolin while vancomycin was predominately used for definite therapy. Future studies to evaluate the clinical outcomes of the antibiotic use to have a better insight on the efficacy of the peritonitis treatment, hence better quality of patient care.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	4127/76014
Uncontrolled Keywords:	Intra-peritoneal; Antibiotics; Continuous Ambulatory Peritoneal Dialysis (CAPD); Peritonitis
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmacy Practice Kulliyyah of Pharmacy
Depositing User:	Prof Dr Che Suraya Mohd Zin
Date Deposited:	12 Nov 2019 15:34
Last Modified:	12 Nov 2019 15:34
URI:	http://irep.iium.edu.my/id/eprint/76014

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