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Effects of different mixing methods towards black seed oil-alginate emulsion characteristics.

Mohd Rus, Shaiqah and Haris @ Harith, Muhammad Salahuddin and Alkhatib, Hamzeh and Mohamed Nasir, Nur 'Abidah and Abu Bakar, Mohd Rushdi and Mohmad Sabere, Awis Sukarni and Mohd Rus, Anika Zafiah and Doolaanea, Abd Almonem (2019) Effects of different mixing methods towards black seed oil-alginate emulsion characteristics. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur.

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Introduction: Black seed oil (BSO) contains active ingredient, thymoquinone which is well-known for its antioxidant property. The bitter taste of BSO makes it hard for the consumers especially children and elderly to consume it daily. Therefore, BSO is encapsulated in alginate beads in micrometre size to improve its palatability. This encapsulation was already established in the lab scale. Production of the beads in a large quantity requires initial preparation of an optimised BSO-alginate emulsion starting with the different mixing methods including the sonication process. Objectives: This study aims to prepare an optimised BSO-alginate emulsion using different types of mixing instruments and flow cell of the sonication process. Materials and Methods: BSO-alginate emulsion was prepared using magnetic stirrer (MS) as the benchmark, overhead stirrer (OS), homogeniser (H) and overhead stirrer combined with homogeniser (OSH). Then, the coarse emulsion was sonicated to produce a stable emulsion. The studied parameters were mixing time, turbidity, droplet size and zeta potential. The results of each mixing method were then analysed statistically. Results: The time taken for alginate to completely dissolve in BSO emulsion for MS, OS, H and OSH were 45, 230, 102 and 46 minutes respectively. Turbidity of BSO-alginate emulsion using OSH was significantly (p<0.05) lower than the benchmark indicates a more stable emulsion. There were no significant differences (p<0.05) between the droplet size and zeta potential of OSH and MS emulsions. Conclusion: OSH gives better emulsion characteristics in terms of lower turbidity, similar mixing time, droplet size and zeta potential compared to MS.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 6657/75507
Uncontrolled Keywords: Black seed oil, alginate, emulsion, overhead stirrer, homogeniser
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr. Muhammad Salahuddin Haris
Date Deposited: 14 Nov 2019 15:18
Last Modified: 26 Nov 2020 15:43
URI: http://irep.iium.edu.my/id/eprint/75507

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