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Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on Streptococcus mutans

Haron, Ummi Aqilah and Mukhtar, Nor Izzah and Omar, Muhammad Nor and Abllah, Zurainie (2019) Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on Streptococcus mutans. Archives of Orofacial Sciences, 14 (2). pp. 1-17. E-ISSN 2231-7163 (In Press)

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Abstract

For decades, coconut oil was reported to possess a broad spectrum of antimicrobial activity due to its abundant fatty acid’s contents. Streptococcus mutans (S. mutans) has been strongly implicated as the main etiological factor in dental caries. Regardless of the ongoing medical advances, the therapeutic resources for dental caries remain ineffectual, and this has led to renewed interest in using virgin coconut oil (VCO) as a possible choice for dental caries control. In this study, the ability of VCO and activated virgin coconut oil (AVCO) combatting cariogenic S. mutans ATCC 25175 has been evaluated. Fatty acids contents were compared through Gas Chromatography-Mass Spectrum (GC-MS) analysis, and their antimicrobial activity was determined using disc diffusion and minimum inhibitory concentration (MIC) test. From the GC-MS analysis, AVCO (59%) was found to have a slightly higher medium-chain fatty acids (MCFA) as compared to VCO (54.1%), and the long-chain fatty acids (LCFA) contents in VCO (45.9%) was found to be higher than AVCO (41%). Interestingly, S. mutans ATCC 25175 was found to be susceptible towards AVCO (MIC: 6.24 mg/ml) and resistance towards VCO in vitro. The excellent antimicrobial activity of AVCO as a result from (i) the release of individuals fatty acids after activation of virgin coconut oil by lipase digestion and (ii) the present of MCFA and LCFA that are significant in antimicrobial activity. Further study can be designed to specifically examine the activity of individuals fatty acids present in oils against S.mutans virulence genes/protein using molecular dynamic assessment.

Item Type: Article (Journal)
Additional Information: 5626/74837
Uncontrolled Keywords: Activated virgin coconut oil; antimicrobial activity; fatty acids; GC-MS analysis; virgin coconut oil
Subjects: R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry > Paediatric Dentistry, Orthodontics & Dental Public Health
Depositing User: Dr zurainie abllah
Date Deposited: 18 Sep 2019 15:01
Last Modified: 18 Sep 2019 15:01
URI: http://irep.iium.edu.my/id/eprint/74837

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