IgE-mediated hypersensitivity to chlorhexidine among first- year dental students

Mohamed Khazin, Sobrina and Abdullah, Dalia and Liew, Amy Kia Cheen and Harun, Nor Adilah and Abdullah, Noormalin and Bun, Can Chong (2019) IgE-mediated hypersensitivity to chlorhexidine among first- year dental students. Allergo Journal International, 28 (6). pp. 204-208. E-ISSN 2197-0378

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Abstract

Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3mL) was drawn and subjected to SIgE test to CHX; sensiti- sation defined as SIgE level of ≥0.10 kUA/L. Results Fifty-eight (98.3%) participants, consisting of 69% (n=40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted. Conclusions Although most participants reported no known exposure to CHX, 8.6% showed CHX sensitisa- tion suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reac- tions in the future.

Item Type:	Article (Journal)
Additional Information:	7195/74563
Uncontrolled Keywords:	ImmunoCAP test · IgE-mediated · Occupational health · Sensitisation · Serum specific
Subjects:	R Medicine > RK Dentistry R Medicine > RL Dermatology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Restorative Dentistry Kulliyyah of Dentistry
Depositing User:	DR NOR ADILAH HARUN
Date Deposited:	19 Mar 2020 15:49
Last Modified:	19 Mar 2020 15:49
URI:	http://irep.iium.edu.my/id/eprint/74563

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