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Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats

Hashim Fauzy, Fatimatuzzahra and Mohd Zainudin, Maizura and Ismawi, Hidayatul Radziah and F T Elshami, Taher (2019) Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats. Evidence-Based Complementary and Alternative Medicine, Volume 2019. pp. 1-8. ISSN 1741-427X E-ISSN 1741-4288

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Abstract

Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures () of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level () and reduced endothelin-1 (ET-1) level () in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.

Item Type: Article (Journal)
Additional Information: 6122/74326
Uncontrolled Keywords: Piper sarmentosum, hypertension, antioxidant aqueous extract, blood pressure
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr Maizura Mohd Zainudin
Date Deposited: 11 Sep 2019 09:39
Last Modified: 26 Sep 2019 16:15
URI: http://irep.iium.edu.my/id/eprint/74326

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