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Psychosocial distress and blood pressure among young adults: role of cortisol as mediator

Wan Omar, Wan Fatein Nabeila and Mohd Shah, Azarisman Shah and Ab Rahman, Jamalludin and A.Talib, Norlelawati and Musa, Ramli and Mohd. Shah, Aida Nur Sharini and Aung, Sithu and Abdullah, Aszrin (2019) Psychosocial distress and blood pressure among young adults: role of cortisol as mediator. International Medical Journal Malaysia, 18 (2). pp. 69-75. ISSN 1823-4631

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Abstract

Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor. The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress in young adults. Methods and materials: A comparative cross-sectional study was conducted in 240 young adults aged 18 to 45 years. The body mass index, waist circumference and blood pressure parameters were recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean (standard deviation) values for SBP, DBP, MAP were 126.0(16.3), 84.1(12.2) and 98.1(13.1) mmHg respectively. Anxiety was significantly associated with systolic blood pressure (β=0.644), diastolic blood pressure (β=0.454) and mean arterial pressure (β=0.516) after adjusting for sex, age and cortisol. However, it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure of the young adults studied. Conclusion: The data suggest that there is no elevated risk for psychosocial distress and hypertension that cortisol poses in young adults.

Item Type: Article (Journal)
Additional Information: 3808/74078
Uncontrolled Keywords: Psychosocial distress, Cortisol, Blood Pressure, Young adults, Mediation
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Internal Medicine
Kulliyyah of Medicine > Department of Psychiatry
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Professor Ramli Musa
Date Deposited: 18 Sep 2019 15:51
Last Modified: 29 Jan 2021 11:00
URI: http://irep.iium.edu.my/id/eprint/74078

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