Psychosocial distress and blood pressure among young adults: role of cortisol as mediator

Wan Omar, Wan Fatein Nabeila and Musa, Ramli and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah and A.Talib, Norlelawati and Aung, Sithu and Abdullah, Aszrin (2018) Psychosocial distress and blood pressure among young adults: role of cortisol as mediator. In: Medical Research Symposium 2018, 9th August 2018, Kuantan, Pahang. (Unpublished)

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Abstract

Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor. The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress in young adults. Methods and materials: A comparative cross-sectional study was conducted in 240 young adults aged 45 years or less. The body mass index, waist circumference and blood pressure parameters were recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean (standard deviation) values for SBP, DBP, MAP were 126.0(16.3), 84.1(12.2) and 98.1(13.1) mmHg respectively. Anxiety was significantly associated with systolic blood pressure (β=0.644), diastolic blood pressure (β=0.454) and mean arterial pressure (β=0.516) after adjusting to sex, age and cortisol. However, it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure of the young adults studied. Conclusion: The data suggests that there is no elevated risk for psychosocial distress and hypertension that cortisol poses in young adults.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	7963/73872
Uncontrolled Keywords:	Psychosocial distress, blood pressure, young adults, cortisol, mediator
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Internal Medicine Kulliyyah of Medicine > Department of Psychiatry Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	DR Aszrin Abdullah
Date Deposited:	15 Apr 2020 11:35
Last Modified:	15 Apr 2020 11:35
URI:	http://irep.iium.edu.my/id/eprint/73872

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