Slc6a4 and Htr2a gene Polymorphisms in Malay-Malaysian Schizophrenia

A.Talib, Norlelawati and Abdullah, Nor Zamzila and Aladzemi, Farah Wahida (2017) Slc6a4 and Htr2a gene Polymorphisms in Malay-Malaysian Schizophrenia. IIUM Press, International Islamic University Malaysia, Kuala Lumpur, Malaysia. ISBN 978-967-418-724-8

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Abstract

Schizophrenia (Sz) affect about 21 million people worldwide. This disorder alters perception, thoughts, affect and behaviour. Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter which has been hypothesized to be abnormal in schizophrenia. The solute carrier family 6 member 4 (SLC6A4) gene and serotonin receptor 2A (HTR2A) gene are among the important genes within the serotonergic system-related genes family. The SLC6A4 gene encode for serotonin transporter (SERT) which regulates the synaptic concentration of serotonin by transporting serotonin molecules back to the pre-synaptic neuron while the HTR2A gene is another gene that encode for the serotonin receptor subtype 2A. Studies done previously failed to produce consistent result for specific locus of schizohrenia susceptibility

Item Type:	Book
Additional Information:	4667/73663
Uncontrolled Keywords:	Slc6a4, Htr2a, Schizophrenia
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine
Depositing User:	Dr Norlelawati A.Talib
Date Deposited:	15 Oct 2019 09:31
Last Modified:	17 Oct 2019 09:50
URI:	http://irep.iium.edu.my/id/eprint/73663

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