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Influence of artocarpus altilis fruit extract on cancer cell

Ganeson, Suhassni and Abdul Jamil, Muhammad Mahadi and Ambar, Radzi and Abdul Wahab, Ridhwan (2019) Influence of artocarpus altilis fruit extract on cancer cell. In: 9th IEEE Control and System Graduate Research Colloquium (ICSGRC 2018), 3rd-4th Aug. 2018, Shah Alam, Selangor.

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Abstract

Conventional chemopreventive agents causes adverse side effects in cancer patients. Thus, this study focuses on the effects of natural plant extract against cancer cell as a way to reduce or detrimental effects of orthodox drugs. The present study emphasizes on anti-cancer potentiality of Artocarpus altilis fruit extract against cervical cancer cell. Cervical cancer cell treated with methanol extract of artocarpus altilis fruit with the concentration varied from 10μg/ml, 20μg/ml, 30μg/ml, 40μg/ml and 50μg/ml. Treated and untreated (cells without treatment) cell proliferation and half maximal inhibitory concentration IC50 measured after 72 hours of incubation. Cells without treatment, 10μg/ml, 20μg/ml, 30μg/ml, 40μg/ml and 50 μg/ml of extract concentration showed 1.3, 0.98, 0.72, 0.65, 0.51, and 0.3 of cell proliferation factor accordingly with 40μg/ml of IC50 value. The result shows that artocarpus altilis is capable in opposing cervical cancer cell proliferation or growth as the proliferation factor decreases with the increasing dose of extract concentration which can be attributed to the presence of bioactive compound in Artocarpus altilis.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 5136/72557
Uncontrolled Keywords: Artocarpus altilis, HeLa cancer cell, cell viability, cell proliferation.
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Dr Ridhwan Abdul Wahab
Date Deposited: 12 Jun 2019 11:22
Last Modified: 12 Jun 2019 11:22
URI: http://irep.iium.edu.my/id/eprint/72557

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