Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Shieh Ting, Kan and Ahmad, Mohamad Syahrizal and Syed Abdul Azziz, Saripah Salbiah and Awang, Khalijah and Mhd Bakri, Yuhanis and Nafiah, Mohd Azlan and Abbas, Phirdaous and Hashim, Yumi Zuhanis Has-Yun (2019) Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. Journal of Research in Pharmacy, 23 (2). pp. 217-223. ISSN 2630-6344

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Abstract

Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data (1H, 13C and LCMS) and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

Item Type:	Article (Journal)
Additional Information:	3774/71573
Uncontrolled Keywords:	Platymitra siamensis ; Annonaceae ; Oxoaporphine alkaloids ; MCF-7 ; Cytotoxic activity.
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	DR YUMI ZUHANIS HAS-YUN HASHIM
Date Deposited:	11 Apr 2019 12:36
Last Modified:	12 Jul 2019 11:24
URI:	http://irep.iium.edu.my/id/eprint/71573

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