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Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital

Akkawi, Muhammad Eid and Nik Mohamed, Mohamad Haniki and Md Aris, Mohd Aznan (2019) Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital. Quality of Life Research. pp. 1-8. ISSN 0962-9343 E-ISSN 1573-2649 (In Press)

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To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods This is a cross-sectional study that took place in a Malaysian tertiary hospital. Patients ≥ 65 years old with at least one medication on admission were recruited. The patients’ prehospitalization medications were reviewed to identify PIMs/ PPOs using version 2 of the STOPP/START criteria. HRQoL was assessed using the EuroQol-5 dimensions (EQ-5D) and EuroQol-visual analog scale (EQ-VAS). The association between the presence of PIM/PPO and the patients’ HRQoL was analyzed using Chi-square and Mann–Whitney U tests. Multiple linear regression models were applied to determine the effect of exposure to PIM/PPO on the patients’ HRQoL, adjusting for confounders. Results Out of 517 patients who fulfilled the inclusion criteria, 502 patients (97%) accepted to be involved in the study and completed the HRQoL questionnaire. The mean (SD) age was 72.4 (5.9) years. 393 (78.3%) of the patients had problems in at least one EQ-5D dimension with pain/discomfort problem being the most reported complaint. The mean (SD) values of the EQ-5D index and the EQ-VAS were 0.734 (0.214) and 59.6 (14.2), respectively, which are lower than those seen in the general Malaysian population. PIM and PPO were found in 28.5% and 45.6% of the patients, respectively. No significant differences were found in the EQ-5D dimensions, EQ-5D index and EQ-VAS between patients who had PIM/PPO and those who did not. Age, sex, and comorbidities were significantly associated with the patients’ HRQoL. Conclusion PIM and PPO are not uncommon among hospitalized elderly patients; however, it does not significantly affect their HRQoL as measured by the EQ-5D-3L instrument.

Item Type: Article (Journal)
Additional Information: 7211/71046
Uncontrolled Keywords: Potentially inappropriate prescribing · Health-related quality of life · Elderly patients · Hospitalization · EQ-5D-3L
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
R Medicine > RZ Other systems of medicine
R Medicine > RZ Other systems of medicine > RZ400 Mental healing
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User: Dr. Muhammad Eid Akkawi
Date Deposited: 12 Mar 2019 14:46
Last Modified: 12 Mar 2019 14:46
URI: http://irep.iium.edu.my/id/eprint/71046

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