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Electrochemical methods to characterize nanomaterial-based transducers for the development of noninvasive glucose sensors

Ismail, Nur Alya Batrisya and Abd-Wahab, Firdaus and Bader, Mamoun M. and Wan Salim, Wan Wardatul Amani (2018) Electrochemical methods to characterize nanomaterial-based transducers for the development of noninvasive glucose sensors. In: Nanotechnology: applications in energy, drug and food. Springer International Publishing AG, pp. 423-439. ISBN 978-3-319-99601-1

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Abstract

Electrochemical biosensors consist of electrodes modified with nanomaterials that contain immobilized biomolecules for analyte recognition and utilize electrochemical transduction; a glucose meter is an example of such a biosensor. Innovation in glucose monitoring includes non-invasive sensing, where alternative body fluids such as saliva can be used in place of blood, eliminating finger-pricking. However, the concentration of glucose in saliva is twofold lower than in blood, demanding a more sensitive transducer. For a decade, research focused on enhancing the transduction layer by modifying electrodes with nanomaterials that can increase electron transfer, enabling detection of glucose at much lower concentrations. The contribution of these nanomaterials towards enhancement of electron transfer can be understood via electrochemical characterization techniques such as cyclic voltammetry (CV), linear sweep voltammetry (LSV), and electrical impedance spectroscopy (EIS). This chapter provides the basis of the voltammetry techniques and EIS with example graphs from our current research. The aforementioned techniques were performed on screen-printed glassy carbon electrodes modified with reduced graphene–conductive polymer composites, with voltammetry measurements providing CV and LSV and EIS measurements, with EIS resulting in Bode and Nyquist plots and Randles equivalent circuit. Results from our study show a reversible electrode reaction that is diffusion controlled.

Item Type: Book Chapter
Additional Information: 7716/70253
Uncontrolled Keywords: nanomaterial-based transducers, noninvasive glucose sensors
Subjects: T Technology > TA Engineering (General). Civil engineering (General) > TA164 Bioengineering
T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Kulliyyah of Engineering
Depositing User: Dr Wan Wardatul Amani Wan Salim
Date Deposited: 14 Feb 2019 11:32
Last Modified: 14 Feb 2019 11:32
URI: http://irep.iium.edu.my/id/eprint/70253

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