GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity

Saleh, Mohammed S M and Mohd Bukhari, Dzatil Awanis and Siddiqui, Mohammad Jamshed Ahmad and Kasmuri, Abdul Razak and Murugesu, Suganya and Khatib, Alfi (2019) GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity. Natural Product Research. ISSN 1478-6419 E-ISSN 1478-6427 (In Press)

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Abstract

ABSTRACT Different extraction processes were employed to extract bioactive metabolites from Salacca zalacca flesh by a range of aqueous and organic solvents. The highest extraction yield was obtained by 50% ethanol extract of SE (73.18 ±4.35%), whereas SFE_1 showed the lowest yield (0.42 ±0.08%). All extracts were evaluated for in vitro a-glucosidase inhibitory activity, measured by their IC50 values in comparison to that of quercetin, the positive control (IC50 ¼ 2.7 ±0.7 lg/mL). The lowest a-glucosidase inhibitory activity was indicated by water extract of SE (IC50 ¼ 724.3 ±42.9 lg/mL) and the highest activity was demonstrated by 60% ethanol extract by UAE (IC50 ¼ 16.2 ± 2.4 lg/mL). All extracts were analysed by GC-MS and identified metabolites like carbohydrates, fatty acids, organic acids, phenolic acids, sterols and alkane-based compounds etcetera that may possess the potential as a-glucosidase inhibitor and may attribute to the a-glucosidase inhibitory activity.

Item Type:	Article (Journal)
Additional Information:	6804/70206
Uncontrolled Keywords:	Salacca zalacca; a-glucosidase; metabolite profiling; GC-MS
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr M Jamshed Siddiqui
Date Deposited:	28 Jan 2019 11:24
Last Modified:	02 Aug 2019 11:37
URI:	http://irep.iium.edu.my/id/eprint/70206

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