Antibacterial and antioxidant activities of extracts from Calophyllum ferrugineum and Calophyllum incrassatum

Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Deny Susanti, Darnis (2018) Antibacterial and antioxidant activities of extracts from Calophyllum ferrugineum and Calophyllum incrassatum. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Vistana Hotel, Kuantan, Pahang. (Unpublished)

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Abstract

Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as ‘bintangor’. There has been a continual interest to further investigate the phytochemistry of Calophyllum sp since this genus is a rich source of active secondary metabolites which showed anti-HIV, cytotoxicity and antimicrobial properties. In this study, antibacterial and antioxidant activities of barks and leaves of C. ferrugineum and C. incrassatum were investigated. Cold extraction method employing dichloromethane, ethyl acetate and methanol as solvent was performed. All extracts were tested for their total phenolic content and antioxidant activities by DPPH radical scavenging and Ferric Reducing Antioxidant Power (FRAP) assays. The methanol extract from the leaves of C. ferrugineum showed the highest TPC value at 122.08 mg GAE/g and the lowest DPPH SC50 value at 11.80 µg/mL. The methanol extract from the barks of C. ferrugineum was found to have the highest FRAP value among all extracts. The antibacterial activity of all extracts was tested by minimum inhibition concentration (MIC) test against Bacillus subtilis, Staphylococcus aureus, Escheria coli and Pseudomonas aeruginosa. Only the dichloromethane extract from bark of C. ferrugineum showed moderate MIC value against Gram positive bacteria, B. subtilis and S. aureus at 125 µg/mL.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	69563/8125
Uncontrolled Keywords:	Calophyllum, C. ferrugineum, C. incrassatum, antioxidant, antibacterial, Guttiferae
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry Kulliyyah of Pharmacy
Depositing User:	Dr Nurul Iman Aminudin
Date Deposited:	30 Jan 2019 12:46
Last Modified:	30 Jan 2019 12:46
URI:	http://irep.iium.edu.my/id/eprint/69563

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