The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions

Ahmed, Qamar Uddin and Malik, Arshi and Azam, Sonish and Hadi, Naghma and Azmi, Asfar Sohail and Parveen, Nazneen and Khan, Nizam Ud Din and Hadi, Sheikh Mumtaz (2004) The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions. Toxicology in Vitro, 18 (4). pp. 435-440. ISSN 0887-2333

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Abstract

Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degradation of DNA. Amentoflavone was found to degrade calf thymus DNA in the presence of Cu(II) at a rate almost twice that of apigenin. Amentoflavone was also shown to reduce Cu(II) to Cu(I) and to generate hydroxyl radicals in the presence of copper ions. In the presence of Cu(II), the absorption spectrum of amentoflavone undergoes a shift and a quenching effect indicating that the biflavonoid is capable of binding to copper ions. Amentoflavone and apigenin were isolated from Cycas rumphii and Trifolium alexandrinum, respectively. The results are discussed in relation to the putative chemopreventive mechanism of amentoflavone.

Item Type:	Article (Journal)
Additional Information:	4921/68936
Uncontrolled Keywords:	flavonoids, amentoflavone DNA,
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	02 Jan 2019 08:10
Last Modified:	02 Jan 2019 08:12
URI:	http://irep.iium.edu.my/id/eprint/68936

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