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Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation

Chatterjee, Bappaditya and Mohammed Hasan, Ali Ebrahim (2018) Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation. In: International Conference on Pharmaceutical Research and Practice, 5th-6th October 2018, Yogjakarta, Indonesia.

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Abstract

Raloxifene, an estrogen receptor modulator, has poor bioavailability due to extensive metabolism and poor solubility. The present work aimed to enhance skin permeation of raloxifene for systematic delivery. Raloxifene nanoemulsion has been developed using various combination of sunflower oil and tween 20- transcutol (surfactant-co-surfactant) followed by the in-vitro characterizations (pH, zeta potential, globule size, thermodynamic stability). Optimized nanoemulsion was converted to nanoemulgel by incorporating carbopol 940 (3% (w/v), pH 6.5) followed by rheology. spreadability, drug loading, toxicity, and ex-vivo permeation studies. Selected formulations resulted in 3.80-3.93 (pH), 24.98-33.8 mV (zeta potential) and 153.10-208.20 nm (globule size) with polydispersity index (<0.259). Developed gel has shown viscoelastic behaviour with acceptable viscosity and spreadability. Drug loading in selected gel, were above 91.41%. Ex-vivo permeation study through rat skin showed significantly higher (>2.5 times) permeation of raloxifene compared to normal gel and solution. FTiR and DSC study revealed alteration of skin fluidity that promotes drug permeation. Nanoemulgel could be a better alternative to deliver raloxifene directly to the circulation through skin due to its nanoscaled size, presence of surfactant and enhanced retention of skin.

Item Type: Conference or Workshop Item (Speech/Talk)
Additional Information: 6923/68359
Uncontrolled Keywords: Raloxifene, nanoemulgel, nanoemulsion, permeation
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Bappaditya Chatterjee
Date Deposited: 10 Dec 2018 14:11
Last Modified: 10 Dec 2018 14:11
URI: http://irep.iium.edu.my/id/eprint/68359

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