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Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts

Murugesu, Suganya and Khatib, Alfi and Ibrahim, Zalikha and Ahmed, Qamar Uddin and Uzir, Bisha Fathamah and Nik Yusoff, Nik Mohd. Idris and Perumal, Vikneswari and Abas, Faridah and Saari, Khozirah (2019) Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts. International Food Research Journal, 26 (1). pp. 319-327. ISSN 1985-4668 E-ISSN 2231-7546

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Abstract

Clinacanthus nutans (C. nutans) is a local plant belongs to the family Acanthaceae. It is consumed as ‘jamu’ (healthy drink) in Indonesia and as ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, its scientific proof on this claim is still lacking. Thus, this study was designed to evaluate the antidiabetic potential and antioxidant capacity of C. nutans leaves extracts using in vitro bioassay tests. The 80% methanolic crude extract of this plant was further partitioned using different polarity solvents viz., hexane, hexane: ethyl acetate (1:1, v/v), ethyl acetate, ethyl acetate: methanol (1:1, v/v) and methanol. All the sub-fractions were analysed for antioxidant effect via 2, 2-diphenyl-2-picrylhydrazil (DPPH) scavenging activity, ferric reducing power (FRAP) and xanthine oxidase (XO) assays followed by antidiabetic evaluation via α-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibitory assays and glucose uptake experiment. The ethyl acetate fraction showed a good antioxidant potential while hexane exhibit high α-glucosidase and DPP-IV enzyme inhibition. The hexane fraction also improved glucose uptake in a dose-dependent manner. The study provides an informative data on the potential of C. nutans to be developed as a functional food in preventing diabetes.

Item Type: Article (Journal)
Additional Information: 6915/68289
Uncontrolled Keywords: Antidiabetic, antioxidant, Clinacanthus nutans, diabetes
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Alfi Khatib
Date Deposited: 05 Dec 2018 15:50
Last Modified: 20 Aug 2019 11:54
URI: http://irep.iium.edu.my/id/eprint/68289

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