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Cytotoxicity and thrombolytic potential of seven different medicinal plant leaves extract

Azad, A.K. and Sarker, Md. Zaidul Islam and Helaluddin, Abul Bashar Mohammed and Alaama, Mohamed and Abdullah, J. (2018) Cytotoxicity and thrombolytic potential of seven different medicinal plant leaves extract. In: 4th International Pharmaceutical Research Conference 2018, 24-26 August 2018, Cyberjaya. (Unpublished)

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Abstract

Background: In practice, either the herbs themselves or the crude extracts are used for traditional remedies but not the isolated molecules. Therefore, the importance of toxicity and clot lysis study of the crude extract is beyond description. Objective: The aim of our study was to find out the preliminary cytotoxic and thrombolytic effect of the seven selected medicinal plant leaves extract. Methods: Cold maceration was performed using ethanol for extraction purposes. The cytotoxicity study was done by using brine shrimp nauplii (Artemia salina) and MTT assays by using MCF-7 cell line. Result: In the cytotoxic activity, out of the seven leaves extract three of them exhibited stronger brine shrimp lethality with 4 TH PHARMACEUTICAL RESEARCH CONFERENCE 2018 Challenging The Inquisitive Minds: Frontier Of The Future 24 – 26 August 2018 | Cyberjaya, Malaysia LC50 122.548 (Uncaria acida), 170.861 (Leea indica) and 175.469 (Piper porphyrophyllum) μg /mL respectively, and on MCF-7 cell line, they also exhibited moderate cytotoxic activity with different concentration of the extract of the same plant leaves such as, Uncaria acida (72.31, 56.22, 38.12 and 9.24%), Leea indica (67.31, 58.22, 43.12 and 15.24%), Piper porphyrophyllum (65.88, 48.12, 40.12 and 21.34%). In thrombolytic assessments, all the leaves extract showed moderate (considering > 20% moderate; **p < 0.01; *p < 0.05) clot lysis activity, but among the extracts, Uncaria cordata (27.36 ± 0.10%) showed the highest and Stachytarpheta indica the lowest (6.14 ± 0.20%) percent clot lysis as compared with the standard streptokinase (65.15 ± 0.16%). Conclusion: This study was conducted to support the folkloric use of seven medicinal plant leaves to improve cancer or myocardial infarction. Although, it is a preliminary screening but it will be targeted to the scientific community to put more attention and to do an extensive and molecular level study in future.

Item Type: Conference or Workshop Item (Invited Papers)
Additional Information: 6605/68159
Uncontrolled Keywords: Cytotoxicity
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 14 Dec 2018 11:51
Last Modified: 05 Jul 2019 08:36
URI: http://irep.iium.edu.my/id/eprint/68159

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