Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum

Awang, Anis Fadhlina Izyani and Ahmed, Qamar Uddin and Ali Shah, Syed Adnan and Md. Jaffri, Juliana and Ghafoor, Kashif and Helal Uddin, A.B.M. and Ferdosh, Sahena and Sarker, Md. Zaidul Islam (2020) Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum. Natural Product Research, 34 (5). pp. 629-637. ISSN 1478-6419 E-ISSN 1478-6427

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Abstract

Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA.

Item Type:	Article (Journal)
Additional Information:	4478/68100
Uncontrolled Keywords:	Stereospermum fimbriatum ; chicha; antibacterial; isolation; angucycline
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Plant Science
Depositing User:	Dr. A. B. M. Helal Uddin
Date Deposited:	04 Dec 2018 09:28
Last Modified:	08 Nov 2022 13:01
URI:	http://irep.iium.edu.my/id/eprint/68100

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