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Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum

Mat Zin, Nik Mohamad Lukman and Abd Mubin, Anis Syazwani and Mohd Nawi, Mohamed Sufian and Helaluddin, Abul Bashar Mohammed and Kasmuri, Abdul Razak and Mandal, Uttam Kumar Umar (2018) Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum. International Medical journal Malaysia (IMJM), 17 (Special Issue 2). pp. 1-4. ISSN 1823-4631

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Abstract

Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that the outcome of our study will result in a suitable formulation that could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month.

Item Type: Article (Meeting Abstract)
Additional Information: 5956/67661
Uncontrolled Keywords: Gliclazide, halal tablet, syariah compliance, sustain release, xanthan gum, natural polymer
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 28 Nov 2018 11:42
Last Modified: 28 Nov 2018 11:42
URI: http://irep.iium.edu.my/id/eprint/67661

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