Zakaria, Fatin Haniza and Abu Bakar, Nor Hidayah and Mohamad, Nasir and Abdul Latif, Ahmad Zubaidi and Mor Japar Khan, Ed Simor Khan and Wan Ahmad, Wan Amir Nizam (2018) The effects of MDMA on brain: An in vivo study in rats. International Journal of Pharmaceutical Research &Allied Sciences, 7 (3). pp. 126-137. ISSN 2277-3657
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Abstract
Background and objective : 3, 4-Methylenedioxymethamphetamine (MDMA) is a powerful central nervous system stimulant that acts by increasing the activity of several neurotransmitter systems. This study aimed to investigate the effect of different doses of MDMA on the level of serotonin in the brain measured from the cerebrospinal fluid (CSF) and their effects on the neurons. Materials and methods : Twenty-six adult male rats were divided into 4 groups. The control group (n=7) received intraperitoneal (IP) injections of 1 mL/gm normal saline twice daily for one week. The MDMA treated groups (n= 6/7) were further subdivided into 3 groups, each receiving 5, 10 or 15mg/kg MDMA intraperitoneal (IP) injections twice daily for one week ; respectively. 24 hours after the last injection of the rats, the CSF was collected. The brains were dissected and processed for paraffin sections and stained by cresyl etch violet stain. Histology, morphometry and statistical analysis were done. Results : The administration of different doses of MDMA significantly increased the level of serotonin in comparison with the control group. The morphometry study indicated that the number of intact neurons in the hippocampus significantly decreased following the administration of different doses of MDMA comparing to the control group. The results also indicated that there was a strong negative correlation between the serotonin levels and the number of intact neurons. Conclusion : MDMA administration even at a low dose had degenerative effects on the neurons in the hippocampus as evidenced by morphometric study, and the intake should be avoided.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 5579/66859 |
| Uncontrolled Keywords: | Serotonin, Cerebrospinal Fluid, MDMA, Cresyl Echt Violet, Neuronal Damage |
| Subjects: | R Medicine > RD Surgery > RD701 Orthopedics |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation Kulliyyah of Medicine |
| Depositing User: | DR ED SIMOR KHAN KHAN |
| Date Deposited: | 22 Oct 2018 14:41 |
| Last Modified: | 22 Oct 2018 14:41 |
| URI: | http://irep.iium.edu.my/id/eprint/66859 |
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