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The use of antidepressants for physical and psychological symptoms in cancer

Zaini, Syahrir N. and Guan, Ng Chong and Sulaiman, Ahmad Hatim and Zainal, Nor Zuraida and Huri, Hasniza Zaman and Shamsudin, Siti Hadijah (2018) The use of antidepressants for physical and psychological symptoms in cancer. Current Drug Targets, 19 (12). pp. 1431-1455. ISSN 1389-4501 E-ISSN 1873-5592

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Cancer patients are commonly associated with various physical and psychological symptoms. In palliative setting, the aims are to relieve those symptoms, improve quality of life, and increase medication adherence among cancer patients. Antidepressants are generally accepted for the treatment of depression among patients with or without cancer. Some other potential benefits of the antidepressants have been reported in cancer patients. Objective: This study aims to review the use of antidepressants for physical and psychological symptoms in cancer patients. Results: Our findings showed the mixed result of positive and negative findings in various symptoms associated with cancer patients. These studies are categorised according to the hierarchy of evidence from high to low level, namely randomised controlled trials, cohort studies, case-control studies, case series, case reports, as well as other type of publications. The majority of antidepressants used in cancer patients seem to be beneficial for the treatment of depression, anxiety, hot flashes and other symptoms such as sexual dysfunction, fatigue, nicotine dependence, vasomotor symptoms, executive functions, sleep problems, pruritus, as well as for hypochondriasis. While fluoxetine was found to be associated with the reduction of antiemetic property in ondansetron, mirtazapine was identified to be a good alternative in treating nausea and cachexia among cancer patients. Conclusion: More research studies with adequate statistical power are warranted to validate the use of antidepressants among cancer patients in treating these physical and psychological symptoms.

Item Type: Article (Journal)
Additional Information: 4916/66745
Uncontrolled Keywords: Antidepressant; Depression; Anxiety; Nausea; Cachexia; Hot flashes; Pain; Cancer.
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RC Internal medicine > RC582 Specialities of Internal Medicine- Immunologic Diseases
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Date Deposited: 10 Oct 2018 09:38
Last Modified: 24 Jan 2019 16:11
URI: http://irep.iium.edu.my/id/eprint/66745

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