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Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used

Zin, Che Suraya and Mohamed Nazar, Nor Ilyani and Ab Rahman, Norny Syafinaz and Alias, Nor Elina and Ahmad, Wan Rohaidah and Rani, Nurul Sahida and Cardosa, Mary Suma and Ng, Kim Swan and Ye, Felicia Loh (2018) Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used. Journal of Pain Research, 11. pp. 1959-1966. ISSN 1178-7090

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Abstract

Purpose: To examine the trends of analgesic prescribing at public tertiary hospital outpatient settings and explore the patterns of their utilization in NSAIDs, tramadol and opioid patients. Patients and methods: This cross sectional study was conducted from 2010 to 2016 using the prescription databases of two tertiary hospitals in Malaysia. Prescriptions for nine NSAIDs (ketoprofen, diclofenac, celecoxib, etoricoxib, ibuprofen, indomethacin, meloxicam, mefenamic acid and naproxen), tramadol and five other opioids (morphine, fentanyl, oxycodone, dihydrocodeine, and buprenorphine) were included in this study. Annual number of patients and prescriptions were measured in repeat cross sectional estimates. Descriptive statistics and linear trend analysis were performed using Stata v13. Results: A total of 192747 analgesic prescriptions of the nine NSAIDs, tramadol, and five other opioids were prescribed for 97227 patients (51.8% NSAIDs patients, 46.6% tramadol patients, and 1.7% opioid patients) from 2010 to 2016. Tramadol (37.9%, n = 72999) was the most frequently prescribed analgesic followed by ketoprofen (17.5%, n=33793), diclofenac (16.2%, n = 31180), celecoxib (12.2%, n =23487), and other NSAIDs (<4.5%). All the analgesics were increased over time except for meloxicam, indomethacin, and mefenamic acid. Opioids, primarily morphine (2.2%, n = 4021) and oxycodone (0.5%, n = 1049), were prescribed the least but the rate of increase was the highest. Conclusion: Tramadol was the most frequently prescribed analgesic at hospital outpatient settings in Malaysia. Opioids were prescribed the least but noted the highest increase in utilization.

Item Type: Article (Journal)
Additional Information: 4127/66546
Uncontrolled Keywords: Trends of prescribing, patterns, analgesics, tramadol, NSAIDs, opioids
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User: Assoc Prof Che Suraya Haji Mohd Zin
Date Deposited: 11 Oct 2018 15:33
Last Modified: 24 Jan 2019 16:17
URI: http://irep.iium.edu.my/id/eprint/66546

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