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Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion

Helal Uddin, Abul Bashar Mohammed and Azad, A.K and Jahan, K and Sathi, T.S. and Sultana, R and Abbas, Syed A (2018) Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion. Journal of Drug Delivery and Therapeutics. pp. 475-480. ISSN 2250-1177

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Abstract

Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. Albendazole is a broad-spectrum antihelmintic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of our study was to improve the dissolution profile of albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was HMPC K 100 LV at 1:10 ratio in solvent evaporation method. The HPMC K 100 LV showed better result for both kneading and solvent evaporation methods. Moreover, among the method employed, solvent evaporation method showed better solubility of drug at 60 min also at 1:10 ratio which was 78.86%. Results indicated that current formulation of solid dispersion is a promising approach for enhancing drug solubility and dissolution.

Item Type: Article (Journal)
Additional Information: 4478/66403
Uncontrolled Keywords: Keywords: Solid dispersion, Albendazole, Solubility, Dissolution, hydrophilic carriers.
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 02 Oct 2018 17:54
Last Modified: 02 Oct 2018 17:54
URI: http://irep.iium.edu.my/id/eprint/66403

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