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Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum

Barudin, Mohd Aiman and Md Isa, Muhammad Lokman and Mat Yusof, Afzan (2018) Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum. Trends in Bioinformatics, 11 (1). pp. 33-43. ISSN 1994-7941 E-ISSN 2077-2254

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Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis of protein sequences and identification of signal peptides on this parasite were analysed by SignalP 4.1 server. A total of 100 protein sequences were randomly selected and analysed, of which 6 (6%) corresponded to be predicted as signal peptide sequences. Results: Based on the comparison of sequences with database protein sequences in GenBank NCBI, almost all protein sequences were highly conserved with other protein sequences from different species of Cryptosporidium. Considering the secretory proteins in Cryptosporidium, several virulence protein sequences of this parasite may also show presence of N-terminal signal peptide or not. Conclusions: Hence, further studies need to be carried out for identification of N-terminal signal peptide function in Cryptosporidium for facilitating its virulence and pathogenesis pathway.

Item Type: Article (Journal)
Additional Information: 5041/65691
Uncontrolled Keywords: Cryptosporidium, N-terminal, peptide, protein, signal.
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Nursing
Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Depositing User: Dr. Afzan Mat Yusof
Date Deposited: 20 Sep 2018 11:42
Last Modified: 24 Jun 2019 16:37
URI: http://irep.iium.edu.my/id/eprint/65691

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