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Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir]

Ab Ghani, Salinda and Abu Bakar, Noor Fitrah and Abu Bakar, Mohd Rushdi and Yusof, Yus Aniza and Abdul Rahman, Norazah (2018) Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir]. Malaysian Journal of Analytical Sciences, 22 (2). pp. 318-325. ISSN 1394-2506

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Abstract

Granulation of mefenamic acid particles was conducted to produce spherical shape, narrow size distribution of granules, high granule strength and good content uniformity by using Pressure Swing Granulation (PSG) technique in a fluidized bed. Two types (binderless and with binder) of granules namely lactose-mefenamic acid (MA) and lactose-polyethylene glycol (PEG)-(MA) with mass ratio of 30:70 and 25:5:70 were produced respectively. The later type of granules was heated for 80 ˚C, above the PEG melting point. Results indicated that all granules were uniform, spherical and narrow size distribution with the average granules size was less than 500 μm. The tensile strength of the lactose-PEG-MA was higher than the lactose-MA due to heating process. The tensile strength of lactose-PEG-MA and lactose-MA with average granules size of 500 μm were 0.42 MPa and 0.33 MPa, respectively. The drug contents in both types of granules were uniform i.e. around 70 ± 0.3 wt.%.

Item Type: Article (Journal)
Additional Information: 4033/65533
Uncontrolled Keywords: mefenamic acid, lactose, polyethylene glycol, pressure swing granulation
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Mohd Rushdi Abu Bakar
Date Deposited: 08 Aug 2018 18:21
Last Modified: 08 Aug 2018 18:21
URI: http://irep.iium.edu.my/id/eprint/65533

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