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Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)

Wan Ali, Wan Ahmad Syahril Rozli (2018) Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD). In: Kuantan CKD-MBD Workshop 2018, 15th July 2018, The Zenith Hotel Kuantan. (Unpublished)

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Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D metabolism; Abnormalities in bone turnover, mineralization, volume linear growth, or strength; and Extraskeletal calcification. This topic reviews the pathogenesis of CKD-MBD. The pathophysiology of the disorder is complex and involves a number of feedback loops between the kidney, bone, intestine, and the vasculature. The main goal of this system is maintenance of calcium and phosphorus balance, often at the expense of abnormalities in other components of the system. While most elements of CKD–MBD are usually present when the glomerular filtration rate (GFR) falls below 40 mL/min, some components may be observed earlier in the course of CKD and precede the onset of clinically detectable abnormalities in serum phosphorus, calcium, PTH, and vitamin D. These include decreased bone formation rates, vascular calcification, loss of klotho, and increased FGF23 secretion.

Item Type: Conference or Workshop Item (Slide Presentation)
Additional Information: 5229/65455
Uncontrolled Keywords: Chronic Kidney Disease, Mineral Bone Disorder (CKD-MBD)
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Internal Medicine
Kulliyyah of Medicine
Depositing User: Dr. Wan Ahmad Syahril Rozli Wan Ali
Date Deposited: 06 Sep 2018 14:58
Last Modified: 06 Sep 2018 14:58
URI: http://irep.iium.edu.my/id/eprint/65455

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