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Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence

Ridzwan, Irna Elina and Suhaimi, Maryam Saadah and Wasli, Nur Syafinaz and Kasmuri, Abdul Razak and Azzubaidi, Marwan Saad and Hashim, Ridzwan and Ahmed, Qamar Uddin and Ming, Long Chiau and Mohamed, Nornisah and Syd Mohmad Faudzi, Syed Mohd Syahmi (2017) Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence. British Journal of Pharmacy, 2 (2). S21-22S. ISSN 2058-8356

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A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor-BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from the previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence.

Item Type: Article (Journal)
Additional Information: 5628/64949
Uncontrolled Keywords: kappa opioid receptor, methamphetamine, polydrug, relapse
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Pharmacy
Depositing User: Dr Irna Elina Ridzwan
Date Deposited: 06 Aug 2018 11:33
Last Modified: 06 Aug 2018 11:33
URI: http://irep.iium.edu.my/id/eprint/64949

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