Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients

Mehdi, Wesen Adel and Mehde, Atheer Awad and Ahmad Raus, Raha and Yusof, Faridah and Zainal Abidin, Zaima Azira and Ghazali, Hamid and Abd Rahman, Azlina and Özacar, Mahmud (2018) Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients. International Journal of Biological Macromolecules, 118 (Part A). pp. 610-616. ISSN 0141-8130

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Abstract

It is assumed that genetic factors play crucial role in nephrolithiasis. The present study was conducted to explore the role of Human Transcription Factor-7 like-2 (TCF7L2) β-defensin (DEFB1) and CD14 gene polymorphism in development and progression of nephrolithiasis. Methods: The genotypes of TCF7L2, DEFB1 and CD14 polymorphism were determined in 240 nephrolithiasis patients and 240 healthy controls by restriction digestion method of PCR. The levels of serum TCF7L2, DEFB1, CD14, uric acid and other biochemical parameters were measured both in nephrolithiasis patients and healthy control. Results: The patients and control groups showed 30% and 50% 1654 AA DEFB1 genotype respectively. The Allele frequency in case of patient’s group was 63.67% while in control group it was 36.33%. The mean serum DEFB1 levels of the patients and control groups attained were 115.66 and 239.43 pg/mL respectively. The allele frequency of TCF7L2 in patients and controls were 44.17% and 70.0% for C-allele, 55.83% and 30.00% for T-allele respectively. The mean of serum TCF7L2 levels were significantly decreased in patients compared to control group.

Item Type:	Article (Journal)
Additional Information:	3911/64936
Uncontrolled Keywords:	TCF7L2CD14β-Defensin
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	zaima azira zainal abidin
Date Deposited:	03 Aug 2018 10:13
Last Modified:	13 Mar 2019 15:17
URI:	http://irep.iium.edu.my/id/eprint/64936

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