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The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis

Akman, Akma Azmiera and Talib, Ain Aisyah and Md Yusof, Azirah and Khalid, Kamarul Ariffin and Yusof, Nurul Asyiqin and Abdul Ghani, Radiah and Hamdan, Asmah Hanim and Zamli, Zaitunnatakhin (2018) The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis. In: The 15th Symposium of the Malaysian Society of Applied Biology (MSAB 2018), 29th June - 1st July 2018, Melaka. (Unpublished)

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Abstract

Osteoarthritis (OA) is a common degenerative joint disease among elderly population. Previous studies have shown that OA is associated with the subchondral bone remodelling. However, none of these studies focuses on the trabecular bone (Tb) remodelling in the epiphyseal region of tibia. Hence, the present study aims to determine the mineral apposition rate (MAR), mineralising surface (MS) and bone formation rate (BFR) of Tb Dunkin Hartley (DH) guinea pigs, and its association with microscopic score of OA. The DH was administered with 20 mg/kg of calcein dye at 9 and 2 days prior to euthanasia. The tibia were then collected at 10, 20 and 30 weeks of age. Histomorphometry and histopathology analyses were conducted to quantify the parameters of Tb remodelling and microscopic OA score, respectively. The data showed that the MAR, MS and BFR were higher in the medial side (versus lateral side) of the tibia (p ≤ 0.05), and increased between 10 and 20 weeks of age. However, at the final time point, these parameters were significantly decreased (p ≤ 0.05), and became lower in the medial than the lateral side of Tb. A strong negative correlation was observed between the BFR and microscopic OA scores (r = -1.0, p ≤ 0.01), suggesting that the Tb loss dominates the late stage of OA.

Item Type: Conference or Workshop Item (Speech/Talk)
Additional Information: 2295/64805
Uncontrolled Keywords: tibial trabecular bone, osteoarthritis
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User: Assoc. Prof. Dr. Kamarul Ariffin Khalid
Date Deposited: 26 Jul 2018 17:23
Last Modified: 26 Jul 2018 17:30
URI: http://irep.iium.edu.my/id/eprint/64805

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