The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management

Abdullah Thaidi, Nur Imanina and Haron, Normah and Darnis, Deny Susanti and Mat Jusoh, Hanapi (2018) The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management. In: 34th International Conference on Natural Products (ICNP 2018), 19th-21st March 2018, Bayview Beach Resort, Pulau Pinang. (Unpublished)

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Abstract

Anacardium occidentale Linn. (A. occidentale L.) commonly known as cashew tree, is a popular tropical plant among local people and has been known to possess an excellent source of bioactive compounds. Bioactive compounds of A. occidentale L. have potency as antidiabetic for type 2 diabetes mellitus (T2DM) management. Some strategies for T2DM management are by maintaining the postprandial glucose level through the inhibition of α-amylase and by preventing the hydrolysis of Glucagon Like Peptide-1 (GLP-1) through the inhibition of Dipeptidyl peptidase IV (DPP-IV). The present study was aimed to investigate the role of bioactive compounds from A. occidentale L. in inhibiting the DPP-IV and α-amylase. HPLC-UV-Vis is used to identify and quantify the phenolic compounds present by comparing with external standards, namely, ferulic acid, p-coumaric acid, gallic acid, kaempferol and quercetin. Three fractions of maceration extracts (shoots and leaves) using methanol as solvent were undergone inhibition analysis by α-amylase assay and DPP-IV Glo protease assay. α-Amylase inhibitory activity was measured using spectrophotometric method at λ = 540 nm with acarbose as positive control. DPP-IV inhibitory activity was measured using luminescent with kaempferol as positive control. All the extracts from shoots and leaves tested revealed there were potent α-amylase and DPP-IV inhibitors, contributing to the inhibition activity significantly. Therefore, A. occidentale L. extracts could serve as a potential source to manage T2DM.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7032/64789
Uncontrolled Keywords:	Anacardium occidentale Linn; Dipeptidyl peptidase IV; α-amylase; inhibitor
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr. Normah Haron
Date Deposited:	27 Jul 2018 10:06
Last Modified:	27 Jul 2018 10:06
URI:	http://irep.iium.edu.my/id/eprint/64789

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