Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square

Saleh, Mohammed S M and Siddiqui, Mohammad Jamshed Ahmad and Mat So'ad, Siti Zaiton and Roheem, Fatimah and Bes-Bes, Salima Saidi and Khatib, Alfi (2018) Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square. Molecules, 23 (6). pp. 1-10. ISSN 1420-3049

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Abstract

Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity.

Item Type:	Article (Journal)
Additional Information:	6804/64259
Uncontrolled Keywords:	α-glucosidase inhibitory activity; fingerprint; Fourier transform infrared spectroscopy; salak fruit
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr M Jamshed Siddiqui
Date Deposited:	28 Jun 2018 15:54
Last Modified:	24 Jan 2019 10:28
URI:	http://irep.iium.edu.my/id/eprint/64259

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