Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum

Ridzuan, P. M. and Mohamad, Nasir and Ismail, Salwani and Abdul Rahman, Nor Iza and Hamzah, Hairul Aini and Buyong, Zunariah and Mohd Hassan, Norazian and Baharudin, Roesnita (2018) Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum. International Medical Journal Malaysia, 17 (1). pp. 31-36. ISSN 1823-4631

	PDF - Published Version Restricted to Repository staff only Download (847kB) | Request a copy
	PDF (scopus) - Supplemental Material Restricted to Repository staff only Download (497kB) | Request a copy
	PDF (WoS) - Published Version Restricted to Registered users only Download (554kB) | Request a copy

Abstract

Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the HC. Microscopic study of the treated fungus was done by transmission electron microscope (TEM). Cytotoxicity study using pre-adipocyte (3T3-L1) cell line was performed by means of MTT cell proliferation assay. The MIC and MFC results of the HC were both 0.49 µg/ml. Microscopic study revealed the destruction of the fungal cell wall and organelles. Cytotoxicity study showed HC to be non-toxic to the tested human cell line. In conclusion, HC may potentially be used as an alternative therapeutic agent against T. rubrum infections.

Item Type:	Article (Journal)
Additional Information:	5342/64138
Uncontrolled Keywords:	Hydroxychavicol, Trichophyton rubrum, antifungal properties, alternative therapeutic.
Subjects:	Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Hairul Aini Hamzah
Date Deposited:	07 Jun 2018 16:25
Last Modified:	01 Aug 2018 11:19
URI:	http://irep.iium.edu.my/id/eprint/64138

Actions (login required)

View Item