Effects of eurycoma longifolia standardized extract on estradiol valerate-induced teratogenicity in female rats

Abdul Rahman, Suzanah and Ahmad, Nur Amalina and Kit-Lam, Chan (2018) Effects of eurycoma longifolia standardized extract on estradiol valerate-induced teratogenicity in female rats. International Journal of Pure and Applied Mathematics, 118 (Special Issue) (24a). pp. 1-23. ISSN 1311-8080 E-ISSN 1314-3395

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Abstract

Estradiol valerate, a synthetic steroidal estradiol is used to treat female reproductive disorders as well as contraception. Consumption of estradiol valerate may produce abortional and teratogenic effects. Possible effects of the standardized extract of Eurycoma longifolia, TAF 273, on foetal development in female rats exposed to estradiol valerate were therefore investigated. Pregnant female rats on day 12 of gestation were administered with a single subcutaneous injection of estradiol valerate (0.15 mg/kg). TAF 273 was administered orally at doses of 25, 50 and 100 mg/kg body weight from day 12 to day 19 of gestation followed by termination of pregnancy on day 21. A decreased the number of live foetuses with high number of post-implantation loss and early resorption were observed. Administration of 100 mg/kg TAF 273 resulted in high number of live foetuses but with decreased body weight and crown-rump length possibly due to competition for space for embryonic development and blood supply. Kyphosis, scoliosis and kinky tail following treatment with estradiol valerate were apparent. Eurycoma longifolia may have potential in ameliorating teratogenic effects of estradiol valerate by reducing external abnormalities in the rat foetuses and may have prospects in the treatment of female-linked disorders and complications.

Item Type:	Article (Journal)
Additional Information:	4493/63946
Uncontrolled Keywords:	Eurycoma longifolia; TAF 273; Teratogenicity; Estradiol Valerate; Foetus
Subjects:	Q Science > Q Science (General) Q Science > QA Mathematics > QA300 Analysis R Medicine > RG Gynecology and obstetrics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Allied Health Sciences
Depositing User:	Prof. Dr. Suzanah Abdul Rahman
Date Deposited:	07 Jun 2018 15:27
Last Modified:	03 Jul 2018 10:13
URI:	http://irep.iium.edu.my/id/eprint/63946

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