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Identification of MSX1 mutation in Malaysian hypodontia family

Muhamad Zamil, Nabilah and Mohamed Yussof, Nor Aini and Ardini, Yunita Dewi and Lestari, Widya (2018) Identification of MSX1 mutation in Malaysian hypodontia family. In: International Dental Conference of Sumatera Utara 2017 (IDCSU 2017), 7th-9th Dec. 2017, Sumatera Utara, Indonesia.

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Hypodontia is defined as the absence of one to six teeth. There is high prevalence of hypodontia recorded in Malaysia (2.8%). This study aimed to identify any mutation of MSX1 in Malaysian family with hypodontia and its clinical finding. We re-examined 4 individuals from a family of the previous PAX9 study. Orthophantomogram (OPG) and intraoral photos were re-assessed. Saliva was collected for genetic analysis. Direct sequencing was done on exons 1 and 2 of MSX1. 2 out of 4 members (1A and 1D) in the family have anterior hypodontia. Point mutation on exon1 of MSX1 (c.731G>A) was observed in 1A (father) with missing 13 and 23 and 1C (carrier-son). c.732G>A was found on exon1 of MSX1 of his daughter (1D) with missing 32.MSX1 mutation is involved in the occurrence of hypodontia in patient.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 6701/63481
Uncontrolled Keywords: MSX1, mutation, hypodontia
Subjects: R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Depositing User: Dr Widya Lestari
Date Deposited: 21 May 2018 09:09
Last Modified: 29 Jun 2018 08:51
URI: http://irep.iium.edu.my/id/eprint/63481

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