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The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings

Shaik Alaudeen, Siti Radziah and Mohd Shah, Azarisman Shah and A.Talib, Norlelawati and Abdullah, Aszrin (2017) The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings. International Medical Journal Malaysia, 16 (Supplementary Issue 1). p. 31. E-ISSN 1823-4631

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Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility to common diseases. However, little is known about CNV role in essential hypertension. Thus, this study aimed to characterize the CNV esv27061 among prehypertensive and hypertensive young adults in Malaysia. Materials and method: In this comparative cross-sectional study, 104 subjects living in Kuantan who gave voluntary consent to participate are recruited and divided into three groups; control (43 subjects), prehypertensive (38 subjects) and mild hypertensive (23 subjects). An optimized droplet digital polymerase chain reaction (ddPCR) was used in the determination of CNV esv27061 in this study. Results: All subjects in the control (n=38; 88.4% gain), prehypertensive (n=33; 86.8% gain) and mild hypertensive (n=21; 91.3% gain) groups had CNV gain (copy number > 2) while 11.6% of control, 13.2% of prehypertensive and 8.7% of mild hypertensive subjects exhibited normal copies (copy number = 2). Conclusion: The present preliminary finding was consistent with the Database of Genomic Variants (DGV) which stated that CNV esv27061 showedmore gain than loss.

Item Type: Article (Meeting Abstract)
Additional Information: 3808/63474
Uncontrolled Keywords: copy number variation, CNV
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Depositing User: DR Aszrin Abdullah
Date Deposited: 30 Aug 2018 11:02
Last Modified: 30 Aug 2018 11:02
URI: http://irep.iium.edu.my/id/eprint/63474

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